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Side-Chain Reactions of Substituted Pyridines
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Problem 5
Side-Chain Reactions of Substituted Pyridines
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27. Heterocycles / Side-Chain Reactions of Substituted Pyridines / Problem 4
Problem 4
Which positions in alkylated pyridines are more acidic and why?
A
C2 and C4 positions are more acidic due to favorable resonance structures involving the nitrogen atom
B
Only the C2 position is more acidic due to its proximity to the nitrogen
C
The acidity is uniform across all positions due to uniform electron distribution
D
C3 and C5 positions are more acidic due to steric hindrance
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