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23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides - Part 1 of 2!
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23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides - Part 1 of 2!
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23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides / Hydrolysis of Thioesters / Problem 5
Problem 5
In the nucleophilic acyl substitution mechanism, what is the role of the nucleophile?
A
The nucleophile forms a hydrogen bond with the solvent.
B
The nucleophile facilitates the formation of a leaving group.
C
The nucleophile protonates the carbonyl oxygen.
D
The nucleophile attacks the carbonyl carbon, forming a tetrahedral intermediate.
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