19. Reactions of Aromatics: EAS and Beyond

Show how the following compounds can be synthesized from benzene:

h. p-nitro-N-methylaniline

Show how each of the following compounds can be synthesized from benzene:

i. 1-phenyl-2-propanol

Show how the following compounds can be synthesized from benzene:

b. m-chloroethylbenzene

Provide the reaction for each of the following reaction steps

Tyramine is an alkaloid found in mistletoe and ripe cheese. Dopamine is a neurotransmitter involved in the regulation of the central nervous system.

b. How can dopamine be prepared from tyramine?

Acetohexamide is used to treat type 2 diabetes that cannot be well controlled by diet alone. Fill in the blanks of the synthetic scheme used to synthesize acetohexamide. [Hints have been provided below each step.]

Show how each of the following compounds can be synthesized from benzene:

f. m-xylene

Show how the following compounds can be synthesized from benzene:

a. N,N,N-trimethylanilinium iodide