5. Chirality

Provide the IUPAC names for the following alkynes.

(b)

Do the following compounds have the R or the S configuration?

a.

b.

Draw a perspective formula for each of the following:

a. (S)-2-chlorobutane

b. (R)-1,2-dibromobutane

What is the configuration of each of the asymmetric centers in the following compounds?

e.

f.

Complete the structure of each of these so that it matches the (R) or (S) configuration associated with the name.

(a)

Assign the absolute stereochemistry for each of the following molecules.

(f)

Prioritize the substituents at each chiral center and then, by each of the two methods discussed in Section 6.3.2.4, determine the absolute configuration. [Do not use your models, except to check your answers.]

(c)

Draw a perspective formula for each of the following:

c. (2S,3R)-3-methyl-2-pentanol

d. (R)-1,2-dibromobutane

In Chapter 12, we introduce the S_N2 reaction, a nucleophilic substitution reaction that proceeds with inversion. Confirm that inversion has occurred in each of the following examples by determining the absolute configuration of the chiral center in the reactants and products.

(a)