5. Chirality

Explain why the enantiomers of 1,2-dimethylaziridine can be separated even though one of the “groups” attached to nitrogen is a lone pair.

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Butaclamol is a potent antipsychotic that has been used clinically in the treatment of schizophrenia. How many asymmetric centers does it have?

(i) Which of the following pairs of compounds would you expect to have different physical properties?

(ii) What is the relationship between each of the pairs?

(iii) Assign the absolute configuration of each stereocenter to confirm your answer.

(c)