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Peptide Sequencing: Partial Hydrolysis with Cyanogen Bromide
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Peptide Sequencing: Partial Hydrolysis with Cyanogen Bromide
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30. Peptides and Proteins / Peptide Sequencing: Partial Hydrolysis with Cyanogen Bromide / Problem 2
Problem 2
What role does the nucleophilic sulfur in methionine play in the mechanism of cyanogen bromide-mediated cleavage?
A
Forms a disulfide bridge.
B
Binds to the peptide backbone, preventing cleavage.
C
Acts as a nucleophile in an SN2 reaction, attacking the carbon adjacent to the bromine.
D
Is oxidized to form sulfoxide.
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