what-role-does-proton-transfer-play-in-the-mechanism-of-nucleophilic-acyl-substi

Question

What role does proton transfer play in the mechanism of nucleophilic acyl substitution during ester hydrolysis?

Accepted Answer

Proton transfer facilitates the conversion of intermediates and the stabilization of transition states.

Answer

Proton transfer acts as a catalyst for the entire reaction.

Answer

Proton transfer is irrelevant in the mechanism of nucleophilic acyl substitution.

Answer

Proton transfer is only necessary for the initial nucleophilic attack.