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27. Heterocycles - Part 2 of 2!
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Problem 11
Problem 12
27. Heterocycles - Part 2 of 2!
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27. Heterocycles / Side-Chain Reactions of Substituted Pyridines / Problem 11
Problem 11
Why are deprotonation at C2 and C4 positions in pyridine more favorable than at C3?
A
C3 lacks resonance stabilization compared to C2 and C4
B
Deprotonation at C3 is hindered by steric effects
C
The electron-withdrawing effect at C3 destabilizes the carbanion
D
Deprotonation at C2 and C4 allows for resonance stabilization through the nitrogen atom
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