Textbook Question
The major inflammatory mediator released by degranulating mast cells in type I hypersensitivity is:
a. Immunoglobulin
b. Complement
c. Histamine
d. Interleukin
e. Prostaglandin
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Ch. 18 - Immune Disorders
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302
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Table of contents
- Ch. 1 - A Brief History of Microbiology31
- Ch. 2 - The Chemistry of Microbiology28
- Ch. 3 - Cell Structure and Function39
- Ch. 4 - Microscopy, Staining, and Classification25
- Ch. 5 - Microbial Metabolism51
- Ch. 6 - Microbial Nutrition and Growth37
- Ch. 7 - Microbial Genetics51
- Ch. 8 - Recombinant DNA Technology21
- Ch. 9 - Controlling Microbial Growth in the Environment36
- Ch. 10 - Controlling Microbial Growth in the Body: Antimicrobial Drugs21
- Ch. 11 - Characterizing and Classifying Prokaryotes29
- Ch. 12 - Characterizing and Classifying Eukaryotes34
- Ch. 13 - Characterizing and Classifying Viruses, Viroids, and Prions23
- Ch. 14 - Infection, Infectious Diseases, and Epidemiology35
- Ch. 15 - Innate Immunity34
- Ch. 16 - Adaptive Immunity21
- Ch. 17 - Immunization and Immune Testing29
- Ch. 18 - Immune Disorders22
- Ch. 19 - Pathogenic Gram-Positive Bacteria25
- Ch. 20 - Pathogenic Gram-Negative Cocci and Bacilli28
- Ch. 21 - Rickettsias, Chlamydias, Spirochetes, and Vibrios25
- Ch. 22 - Pathogenic Fungi47
- Ch. 23 - Parasitic Protozoa, Helminths, and Arthropod Vectors44
- Ch. 24 - Pathogenic DNA Viruses23
- Ch. 25 - Pathogenic RNA Viruses30
- Ch. 26 - Applied and Industrial Microbiology29
- Ch. 27 - Microbial Ecology and Microbiomes22
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302Not the one you use?Change textbook
Chapter 18, Problem 1
The immunoglobulin class that mediates type I hypersensitivity is:
a. IgA
b. IgM
c. IgG
d. IgD
e. IgE
Verified step by step guidance1
Understand that type I hypersensitivity reactions are immediate allergic reactions mediated by a specific class of immunoglobulin.
Recall the functions of different immunoglobulin classes: IgA is mainly found in mucosal areas, IgM is the first antibody produced in an immune response, IgG is the most abundant antibody in serum, IgD is primarily a receptor on B cells, and IgE is involved in allergic responses.
Identify that type I hypersensitivity involves the binding of an allergen to IgE antibodies attached to mast cells and basophils, leading to the release of histamine and other mediators.
Conclude that the immunoglobulin class responsible for mediating type I hypersensitivity is IgE.
Match the correct answer choice to IgE, which is option e.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Type I Hypersensitivity
Type I hypersensitivity is an immediate allergic reaction triggered by allergens, leading to symptoms like itching, swelling, and anaphylaxis. It involves the activation of mast cells and basophils through antibody binding, causing the release of histamine and other mediators.
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01:06
Types of Phosphorylation
Immunoglobulin E (IgE)
IgE is a class of antibodies primarily involved in allergic responses and defense against parasitic infections. It binds to allergens and triggers mast cell degranulation, which releases histamine and other chemicals responsible for type I hypersensitivity symptoms.
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Other Immunoglobulin Classes
Immunoglobulins like IgA, IgM, IgG, and IgD have distinct roles: IgA protects mucosal surfaces, IgM is the first antibody in immune responses, IgG provides long-term immunity, and IgD functions mainly as a B cell receptor. None of these mediate type I hypersensitivity.
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03:48Review Table of Immunoglobin Classes
Related Practice
Textbook Question
Put the number of the type of immune system hypersensitivity in the blank next to each manifestation. Each of the four types may be used more than once or not at all. If the manifestation is not an immune hypersensitivity, put zero in the blank.
1. Acute anaphylaxis
2. Allergic contact dermatitis
3. Systemic lupus erythematosus
4. Allograft rejection
5. AIDS
6. Graft-versus-host disease
7. Milk allergy
8. Rheumatoid arthritis (RA)
9. Asthma
10. Hay fever
I. Type I hypersensitivity
II. Type II hypersensitivity
III. Type III hypersensitivity
IV. Type IV hypersensitivity
0. Not a hypersensitivity
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Textbook Question
Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
________ Cyclosporine is released by degranulating mast cells.
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Textbook Question
Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
_____ Type III hypersensitivity reactions may lead to the development of glomerulonephritis.
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Textbook Question
Why is a child born to an Rh+ mother not susceptible to Rh-related hemolytic disease of the newborn?
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Textbook Question
Label the four types of grafts on the accompanying figure.
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