8. Protein Function

Choose all of the following molecules that, when bound, trigger hemoglobin's transition from T to R state.

Alkalemia is a disease associated with an abnormal increase in the pH of a patient's blood due to rapid breathing (hyperventilation). How would alkalemia affect the oxygen binding affinity of the patient's hemoglobin?

Which statement is true about protons binding to hemoglobin?

Which option best corresponds with the effect of CO₂ on hemoglobin's O₂-binding?