Textbook Question
If you were to cut through epithelial tissue without penetrating the basement membrane, would you expect bleeding to occur? Why or why not?
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Ch. 4 Histology
Amerman2nd EditionHuman Anatomy & PhysiologyISBN: 9780136873822
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Table of contents
- Ch. 1 Introduction to Anatomy and Physiology26
- Ch. 2 The Chemistry of Life38
- Ch. 3 The Cell55
- Ch. 4 Histology47
- Ch. 5 The Integumentary System30
- Ch. 6 Bones and Bone Tissue36
- Ch. 7 The Skeletal System40
- Ch. 8 Articulations19
- Ch. 9 The Muscular System36
- Ch. 10 Muscle Tissue and Physiology29
- Ch. 11 Introduction to the Nervous System and Nervous Tissue28
- Ch. 12 The Central Nervous System42
- Ch. 13 The Peripheral Nervous System41
- Ch. 14 The Autonomic Nervous System and Homeostasis31
- Ch. 15 The Special Senses39
- Ch. 16 The Endocrine System42
- Ch. 17 The Cardiovascular System I: The Heart30
- Ch. 18 The Cardiovascular System II: The Blood Vessels43
- Ch. 19 Blood32
- Ch. 20 The Lymphatic System and Immunity45
- Ch. 21 The Respiratory System27
- Ch. 22 The Digestive System27
- Ch. 23 Metabolism and Nutrition7
- Ch. 24 The Urinary System39
- Ch. 25 Fluid, Electrolyte, and Acid-Base Homeostasis39
- Ch. 26 The Reproductive System10
- Ch. 27 Development and Heredity5
Chapter 4, Problem L2.4
Certain types of cancerous lung tumors can secrete hormones normally made by the pancreas, adrenal gland, and hypothalamus. What prevents such secretion from happening in healthy cells?
Verified step by step guidance1
Understand the concept of cellular differentiation: Healthy cells are specialized to perform specific functions based on their location and role in the body. This specialization prevents them from producing substances unrelated to their function.
Learn about gene expression regulation: In healthy cells, genes responsible for producing hormones like those made by the pancreas, adrenal gland, and hypothalamus are tightly regulated and typically inactive in lung cells. This regulation ensures that lung cells do not produce hormones meant for other organs.
Explore the role of signaling pathways: Healthy cells rely on specific signaling pathways to maintain their function. These pathways prevent the activation of genes that are not relevant to the cell's role, ensuring proper cellular behavior.
Understand the impact of mutations in cancerous cells: Cancerous cells often have mutations that disrupt normal gene regulation. These mutations can lead to the activation of genes that are normally inactive in lung cells, causing the secretion of hormones typically made by other organs.
Recognize the importance of tissue-specific transcription factors: Healthy cells have tissue-specific transcription factors that control which genes are expressed. In lung cells, these factors prevent the expression of genes responsible for hormone production in other tissues.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Hormonal Regulation
Hormonal regulation refers to the mechanisms by which hormones are produced, released, and controlled within the body. In healthy cells, this regulation ensures that hormones are secreted only by their respective glands in response to specific physiological signals, maintaining homeostasis and preventing inappropriate hormone release.
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Cellular Differentiation
Cellular differentiation is the process by which unspecialized cells develop into specialized cells with distinct functions. Healthy cells are differentiated to perform specific roles, which includes the regulation of hormone production, ensuring that only certain cells, like those in the pancreas or adrenal glands, can secrete their respective hormones.
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Tumorigenesis
Tumorigenesis is the process by which normal cells transform into cancerous cells, often leading to uncontrolled growth and abnormal functions. In certain lung tumors, this process can result in the aberrant secretion of hormones, as cancer cells may acquire the ability to mimic the functions of hormone-producing cells, disrupting normal hormonal balance.
Related Practice
Textbook Question
Why do you think the rate of cell division is different for different tissues? Where in the body would you expect to find cells that have a rapid rate of division? Where might you find cells that have a slow rate of division? Explain.
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Textbook Question
In the disease pulmonary fibrosis, elastic fibers of the lung are destroyed and replaced with collagen fibers. Predict the effect this would have on breathing.
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Textbook Question
Epithelial cells of the kidneys have pumps that drive the transcellular transport of sodium ions.
Is this epithelium likely to be simple or stratified? Why?
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Textbook Question
Predict which organelles are likely to be abundant in cells such as fibroblasts that actively produce and secrete proteins.
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Textbook Question
Vitamin C is required for the synthesis of collagen. Predict the effect that a vitamin C deficiency (a disease called scurvy) would have on bone tissue, dense regular collagenous connective tissue, dense irregular connective tissue, and cartilage. What symptoms would you expect to see from this disease?
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