Multiple Choice
Starting from polystyrene, provide the synthetic pathway in forming the tripeptide Gly-Leu-Ser using the Merrifield peptide synthesis method.
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- 1. A Review of General Chemistry5h 6m
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- 29. Amino Acids4h 20m
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- Reactions of Amino Acids: Esterification7m
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- 30. Peptides and Proteins2h 42m
- Peptides12m
- Primary Protein Structure4m
- Secondary Protein Structure17m
- Tertiary Protein Structure11m
- Disulfide Bonds17m
- Quaternary Protein Structure10m
- Summary of Protein Structure7m
- Intro to Peptide Sequencing2m
- Peptide Sequencing: Partial Hydrolysis25m
- Peptide Sequencing: Partial Hydrolysis with Cyanogen Bromide7m
- Peptide Sequencing: Edman Degradation28m
- Merrifield Solid-Phase Peptide Synthesis18m
- 31. Catalysis in Organic Reactions1h 30m
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- 34. Nucleic Acids1h 32m
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- Electron Configuration of Elements45m
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- The 18 and 16 Electron Rule13m
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- Suzuki Reaction25m
- Sonogashira Coupling Reaction17m
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- Negishi Coupling Reaction16m
- Buchwald-Hartwig Amination Reaction19m
- Eglinton Reaction17m
- Catalytic Allylic Alkylation18m
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- 36. Synthetic Polymers1h 49m
- Introduction to Polymers6m
- Chain-Growth Polymers10m
- Radical Polymerization15m
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30. Peptides and Proteins
Merrifield Solid-Phase Peptide Synthesis
Multiple Choice
Provide the peptide chain structure produced from the following sequence of reagents. (Note: Show the ionic forms for the N and C terminus ends).
A
B
C
D
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Verified step by step guidance1
Identify the sequence of amino acids from the given reagents. The reagents are protected amino acids, and the sequence is T (Threonine), F (Phenylalanine), L (Leucine), and G (Glycine).
Understand that the peptide synthesis involves coupling these amino acids in the given order. The protecting groups are removed using H3O+ and HF, which are common deprotection reagents.
Draw the peptide backbone by connecting the amino acids through peptide bonds. A peptide bond is formed between the carboxyl group of one amino acid and the amino group of the next.
Ensure the N-terminus (the start of the peptide chain) is in its ionic form, typically as NH3+, and the C-terminus (the end of the peptide chain) is in its ionic form, typically as COO-.
Verify the structure by checking that each amino acid is correctly represented and that the sequence matches the order given by the reagents: Threonine, Phenylalanine, Leucine, Glycine.
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