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Ch.12 Food as Fuel An Overview of Metabolism
Frost - General, Organic and Biological Chemistry 4th Edition
Frost4th EditionGeneral, Organic and Biological ChemistryISBN: 9780134988696Not the one you use?Change textbook
All textbooksFrost 4th EditionCh.12 Food as Fuel An Overview of MetabolismProblem 98
Chapter 8, Problem 98

A person is brought to the emergency room in what appears to be a drunken stupor. On closer examination, she seems to be breathing very rapidly and you notice a sweet-smelling odor on her breath. You find out this person has not been drinking alcohol. What is her likely condition?

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1
Step 1: Recognize the symptoms described in the problem. The person is breathing rapidly (hyperventilation) and has a sweet-smelling odor on their breath. These are key clinical observations.
Step 2: Understand that the sweet-smelling odor on the breath is often associated with the presence of ketones, which are produced during fat metabolism. This can occur when the body is unable to use glucose effectively for energy.
Step 3: Recall that rapid breathing (hyperventilation) can be a compensatory mechanism for metabolic acidosis, a condition where the blood becomes too acidic. This is often seen in conditions like diabetic ketoacidosis (DKA).
Step 4: Consider the possibility of diabetic ketoacidosis (DKA) as the likely condition. DKA occurs when there is insufficient insulin, leading to high blood glucose levels and the breakdown of fats into ketones, which can cause the sweet-smelling breath and acidosis.
Step 5: Conclude that the person should be tested for blood glucose levels, ketone levels, and blood pH to confirm the diagnosis of diabetic ketoacidosis and begin appropriate medical treatment immediately.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Diabetic Ketoacidosis (DKA)

Diabetic Ketoacidosis is a serious complication of diabetes that occurs when the body starts breaking down fats at an excessive rate, leading to the production of ketones. This condition often arises in individuals with type 1 diabetes and can result in symptoms such as rapid breathing, confusion, and a sweet, fruity odor on the breath due to the presence of acetone.
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Acidosis

Acidosis refers to an excess of acid in the body fluids, which can occur in various medical conditions, including DKA. In this state, the blood pH drops below normal levels, leading to metabolic disturbances. The body attempts to compensate for this by increasing respiratory rate to expel carbon dioxide, which can manifest as rapid breathing.

Differential Diagnosis

Differential diagnosis is the process of distinguishing a particular disease or condition from others that present with similar clinical features. In this scenario, the presence of rapid breathing and a sweet odor on the breath necessitates considering conditions like DKA, rather than alcohol intoxication, to arrive at the correct diagnosis and treatment plan.
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Related Practice
Textbook Question

Lauric acid, a saturated fatty acid, [12:0], is found in coconut oil.

a. Draw fatty acyl lauric acid activated for β oxidation.

Textbook Question

Excess nitrogen in the body can form uric acid crystals responsible for the painful condition called gout. Besides proteins, name a biomolecule synthesized in the body that uses nitrogen.

Textbook Question

Can acetyl CoA feed into gluconeogenesis, producing glucose for the body? Can fatty acids be used to produce glucose?

Textbook Question

Lauric acid, a saturated fatty acid, [12:0], is found in coconut oil.

e. How many cycles of β oxidation occur?

Textbook Question

Consider the complete oxidation of arachidic acid, a saturated fatty acid, [20:0].

b. How many cycles of β oxidation occur?