Textbook Question
Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?
d. Glycogenesis
Ch.22 Carbohydrate Metabolism
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187
Not the one you use?Change textbookSelect a different textbook
Table of contents
- Ch.1 Matter and Measurements27
- Ch.2 Atoms and the Periodic Table20
- Ch.3 Ionic Compounds8
- Ch.4 Molecular Compounds23
- Ch.5 Classification & Balancing of Chemical Reactions12
- Ch.6 Chemical Reactions: Mole and Mass Relationships28
- Ch.7 Chemical Reactions: Energy, Rate and Equilibrium64
- Ch.8 Gases, Liquids and Solids24
- Ch.9 Solutions52
- Ch.10 Acids and Bases25
- Ch.11 Nuclear Chemistry22
- Ch.12 Introduction to Organic Chemistry: Alkanes57
- Ch.13 Alkenes, Alkynes, and Aromatic Compounds47
- Ch.14 Some Compounds with Oxygen, Sulfur, or a Halogen50
- Ch.15 Aldehydes and Ketones45
- Ch.16 Amines42
- Ch.17 Carboxylic Acids and Their Derivatives57
- Ch.18 Amino Acids and Proteins82
- Ch.19 Enzymes and Vitamins63
- Ch.20 Carbohydrates44
- Ch.21 The Generation of Biochemical Energy65
- Ch.22 Carbohydrate Metabolism45
- Ch.23 Lipids42
- Ch.24 Lipid Metabolism33
- Ch.25 Protein and Amino Acid Metabolism24
- Ch.26 Nucleic Acids and Protein Synthesis45
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187Not the one you use?Change textbook
Chapter 22, Problem 23b
Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?
b. Hydrolysis to free glucose
Verified step by step guidance1
Understand the role of glucose 6-phosphate: Glucose 6-phosphate is a phosphorylated glucose molecule that serves as an intermediate in various metabolic pathways, including glycolysis, gluconeogenesis, and the pentose phosphate pathway.
Recognize the process of hydrolysis: Hydrolysis is a chemical reaction where a water molecule is used to break a bond. In this case, the phosphate group is removed from glucose 6-phosphate, resulting in free glucose and inorganic phosphate.
Identify the conditions for hydrolysis to free glucose: Hydrolysis of glucose 6-phosphate to free glucose typically occurs in the liver and kidneys. This process is catalyzed by the enzyme glucose-6-phosphatase, which is present in these organs.
Relate to physiological conditions: The hydrolysis to free glucose occurs when the body needs to maintain blood glucose levels, such as during fasting or between meals. This is part of the gluconeogenesis or glycogenolysis pathways, where glucose is released into the bloodstream to provide energy to other tissues.
Summarize the key point: Hydrolysis of glucose 6-phosphate to free glucose occurs under conditions where the body requires glucose to be released into the bloodstream, such as during low blood sugar levels or energy demand, and is facilitated by the enzyme glucose-6-phosphatase in specific tissues.
Verified video answer for a similar problem:
This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
6mWas this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Glucose 6-Phosphate Metabolism
Glucose 6-phosphate (G6P) is a key intermediate in several metabolic pathways, including glycolysis and the pentose phosphate pathway. It can be converted into glucose through hydrolysis, which is essential for maintaining blood sugar levels. Understanding the role of G6P in metabolism helps clarify how the body regulates energy production and storage.
Recommended video:
Guided course
2:07
Total Energy From Glucose Concept 1
Conditions for Hydrolysis
The hydrolysis of glucose 6-phosphate to free glucose primarily occurs in the liver and is stimulated by the hormone glucagon during fasting or low blood sugar conditions. This process is facilitated by the enzyme glucose-6-phosphatase, which is present in the liver but absent in most other tissues, allowing the liver to release glucose into the bloodstream when needed.
Recommended video:
Guided course
1:07Basic Hydrolysis Concept 2
Hormonal Regulation
Hormonal regulation plays a crucial role in determining the fate of glucose 6-phosphate. Insulin promotes the conversion of glucose to G6P for storage as glycogen, while glucagon and epinephrine stimulate its hydrolysis to free glucose during periods of energy demand. This balance between hormones ensures that glucose levels remain stable in the body.
Recommended video:
Guided course
2:57Allosteric Control Concept 1
Related Practice
Textbook Question
Outline the conditions that direct pyruvate toward the following:
c. Conversion to lactate
In what tissues or organisms is each pathway present?
Textbook Question
Outline the conditions that direct pyruvate toward the following:
b. Conversion to ethanol and CO2
In what tissues or organisms is each pathway present?
Textbook Question
What is the purpose of the Cori cycle?
Textbook Question
Glycolysis of one molecule of glucose produces 8 ATP molecules. How many ATP molecules are produced from glycolysis of 10 glucose molecules?
Textbook Question
What two types of reactions convert glycerol to dihydroxyacetone phosphate?