Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Is the bond in part (f) a covalent or a noncovalent bond?
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Ch. 7 - DNA Structure and Replication
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 7, Problem 5h
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What term is used to describe the pattern of base pairing between one DNA strand and its partner in a duplex?
Verified step by step guidance1
The term used to describe the pattern of base pairing between one DNA strand and its partner in a duplex is 'complementary base pairing.' This refers to the specific pairing of nitrogenous bases in DNA.
In DNA, adenine (A) pairs with thymine (T) through two hydrogen bonds, and cytosine (C) pairs with guanine (G) through three hydrogen bonds. This ensures the strands are complementary to each other.
To determine the complementary strand for the given sequence, write the sequence of the original strand: 5'-ATCGACCTGATC-3'.
Next, replace each base with its complementary base: A with T, T with A, C with G, and G with C. This will give the complementary sequence.
Finally, reverse the direction of the complementary sequence to ensure it is written in the 5' to 3' direction, as DNA strands are antiparallel. This means the complementary strand will be written as 3'-TAGCTGGACTAG-5'.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Base Pairing
Base pairing refers to the specific hydrogen bonding between nitrogenous bases in DNA. In a duplex DNA structure, adenine (A) pairs with thymine (T) through two hydrogen bonds, while cytosine (C) pairs with guanine (G) through three hydrogen bonds. This complementary pairing is crucial for the stability of the DNA double helix and ensures accurate replication and transcription.
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Base Distortions
Antiparallel Orientation
DNA strands are oriented in an antiparallel fashion, meaning that one strand runs in the 5' to 3' direction while the complementary strand runs in the 3' to 5' direction. This orientation is essential for the proper alignment of base pairs and is critical during DNA replication and transcription, as enzymes that synthesize DNA and RNA can only add nucleotides to the 3' end of a growing strand.
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Duplex DNA Structure
Duplex DNA structure refers to the double helical formation of DNA, consisting of two intertwined strands held together by base pairs. This structure was famously described by Watson and Crick and is fundamental to the storage of genetic information. The stability and integrity of the duplex are vital for cellular processes such as replication, repair, and gene expression.
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Related Practice
Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What enzymes catalyze the reaction in part (d)?
Textbook Question
The principles of complementary base pairing and antiparallel polarity of nucleic acid strands in a duplex are universal for the formation of nucleic acid duplexes. What is the chemical basis for this universality?
Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Identify the bond that joins one strand of a DNA duplex to the other strand.
Textbook Question
For the following fragment of DNA, determine the number of hydrogen bonds and the number of phosphodiester bonds present:
5'-ACGTAGAGTGCTC-3'
3'-TGCATCTCACGAG-5'
Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What term is used to describe the polarity of two DNA strands in a duplex?