Textbook Question
Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?
Individual sequencing (personal genomics) identifies a mutation associated with Alzheimer's disease.
Ch. 22 - Applications of Genetic Engineering and Biotechnology
Klug12th EditionConcepts of Genetics ISBN: 9780135564776
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Table of contents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
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Klug 12th EditionCh. 22 - Applications of Genetic Engineering and BiotechnologyProblem 9c
Klug 12th EditionCh. 22 - Applications of Genetic Engineering and BiotechnologyProblem 9cChapter 22, Problem 9c
Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?
DNA sequencing of a breast tumor reveals mutations in the BRCA1 gene.
Verified step by step guidance1
Understand the difference between prognostic and diagnostic tests: Diagnostic tests are used to identify the presence of a disease or condition, while prognostic tests predict the likely course or outcome of a disease.
Analyze the context of the example: DNA sequencing of a breast tumor is performed to identify mutations in the BRCA1 gene, which is associated with breast cancer.
Determine if the test is diagnostic: If the sequencing is used to confirm the presence of a BRCA1 mutation in the tumor, it is diagnostic because it identifies a specific genetic alteration linked to the disease.
Determine if the test is prognostic: If the sequencing is used to assess how the BRCA1 mutation might influence the progression, severity, or treatment response of the breast cancer, it is prognostic.
Conclude the classification: Based on the purpose of the test (diagnosis or prediction of disease outcome), classify the example as either diagnostic or prognostic.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Prognostic vs. Diagnostic Testing
Prognostic tests are used to predict the likely course or outcome of a disease, while diagnostic tests are designed to confirm the presence of a disease or condition. Understanding the distinction is crucial for interpreting genetic testing results, as it informs treatment decisions and patient management.
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Traditional vs. Next-Gen
BRCA1 Gene and Its Role in Cancer
The BRCA1 gene is a critical gene involved in the repair of DNA breaks. Mutations in this gene are associated with an increased risk of breast and ovarian cancers. Identifying mutations in BRCA1 through genetic testing can provide insights into a patient's cancer risk and inform both prognostic and diagnostic evaluations.
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DNA Sequencing
DNA sequencing is a method used to determine the exact sequence of nucleotides in a DNA molecule. In the context of genetic testing, sequencing can identify specific mutations that may be linked to diseases, helping to classify whether a test is prognostic or diagnostic based on the findings and their implications for patient care.
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Related Practice
Textbook Question
Does genetic analysis by ASO testing allow for detection of epigenetic changes that may contribute to a genetic disorder? Explain your answer.
Textbook Question
Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?
ASO testing determines that an individual is a carrier for the mutant β-globin allele (βˢ) found in sickle-cell anemia.
Textbook Question
Might it make sense someday to sequence every newborn's genome at the time of birth? What are the potential advantages and concerns of this approach?
Textbook Question
Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?
An adult diagnosed with Asperger syndrome (AS) has a genetic test that reveals an SNP in the GABRB3 gene that is significantly more common in people with AS than the general population.
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Textbook Question
Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?
Genetic testing in a healthy teenager identifies an SNP correlated with autism.
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