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Ch. 12 Nervous Tissue
Martini - Fundamentals of Anatomy and Physiology 12th Edition
Martini, Nath, Bartholomew12th EditionFundamentals of Anatomy and PhysiologyISBN: 9780137854011Not the one you use?Change textbook
Chapter 12, Problem 4

Phagocytic cells in nervous tissue of the CNS are:
(a) Astrocytes
(b) Ependymal cells
(c) Oligodendrocytes
(d) Microglia.

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1
Understand the role of phagocytic cells in the central nervous system (CNS). Phagocytic cells are responsible for engulfing and digesting cellular debris, pathogens, and dead cells to maintain a healthy environment in the CNS.
Review the functions of each cell type listed: Astrocytes provide structural support and regulate the blood-brain barrier; Ependymal cells line the ventricles and help circulate cerebrospinal fluid; Oligodendrocytes produce myelin sheaths around CNS axons; Microglia act as the resident immune cells and perform phagocytosis.
Identify which cell type is specialized for phagocytosis. Since microglia are the immune cells of the CNS, they are the primary phagocytic cells responsible for removing waste and pathogens.
Confirm that microglia are derived from the same lineage as macrophages and have the ability to migrate and engulf harmful substances, distinguishing them from the other glial cells.
Conclude that the correct answer is microglia, as they are the phagocytic cells in nervous tissue of the CNS.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Phagocytic Cells in the CNS

Phagocytic cells are specialized cells that engulf and digest cellular debris and pathogens. In the central nervous system (CNS), these cells help maintain homeostasis and protect neural tissue by removing harmful substances.
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Microglia

Microglia are the primary phagocytic cells of the CNS. They act as the brain's resident immune cells, constantly surveying the environment and responding to injury or infection by engulfing damaged cells and pathogens.

Other Glial Cells in the CNS

Astrocytes, ependymal cells, and oligodendrocytes are other types of glial cells in the CNS. While they support neurons in various ways, such as nutrient supply, forming myelin, or producing cerebrospinal fluid, they do not have phagocytic functions like microglia.
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