Skip to main content
Ch. 11 Fundamentals of the Nervous System and Nervous Tissue
Marieb - Human Anatomy & Physiology 7th Edition
Marieb, Hoehn7th EditionHuman Anatomy & PhysiologyISBN: 9780805359091Not the one you use?Change textbook
All textbooksMarieb, Hoehn 7th EditionCh. 11 Fundamentals of the Nervous System and Nervous TissueProblem 26
Chapter 11, Problem 26

In the Netherlands a young man named Jan was admitted to the emergency room. He and his friends had been to a rave. His friends say he started twitching and having muscle spasms which progressed until he was 'stiff as a board.' On examination, staff found a marked increase in muscle tone and hyperreflexia involving facial and limb muscles. In his pocket, he had unmarked dark yellow tablets with dark flecks. Analysis of the tablets showed them to contain a mixture of ecstasy and strychnine. Ecstasy would not cause this clinical picture, but strychnine, which blocks glycine receptors, could. Explain how.

Verified step by step guidance
1
Understand the role of glycine in the nervous system: Glycine is an inhibitory neurotransmitter primarily found in the spinal cord and brainstem. It binds to glycine receptors on motor neurons, causing chloride ions (Cl⁻) to enter the neuron, which hyperpolarizes the cell and reduces its excitability.
Recognize the effect of strychnine on glycine receptors: Strychnine acts as a competitive antagonist at glycine receptors, meaning it blocks glycine from binding and prevents the inhibitory effect. This leads to decreased chloride influx and reduced inhibition of motor neurons.
Analyze the consequence of blocking glycine receptors: Without glycine-mediated inhibition, motor neurons become hyperexcitable. This results in increased muscle tone (rigidity), muscle spasms, and hyperreflexia, as the normal 'braking' effect on motor neuron firing is lost.
Connect the symptoms to the mechanism: The patient's stiffness ('stiff as a board'), muscle spasms, and hyperreflexia are explained by the loss of glycine inhibition due to strychnine, causing uncontrolled motor neuron activity and excessive muscle contraction.
Summarize the clinical picture: Although ecstasy does not cause these symptoms, the presence of strychnine in the tablets explains the observed neurological signs by blocking glycine receptors and disrupting inhibitory neurotransmission in the spinal cord and brainstem.

Verified video answer for a similar problem:

This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
2m
Was this helpful?

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Role of Glycine as an Inhibitory Neurotransmitter

Glycine is a key inhibitory neurotransmitter in the spinal cord and brainstem that reduces neuronal excitability by opening chloride channels, leading to hyperpolarization of neurons. This inhibition helps regulate muscle tone and reflexes, preventing excessive muscle contraction and spasms.
Recommended video:
2:30
Neurotransmitter Receptors

Mechanism of Strychnine Toxicity via Glycine Receptor Blockade

Strychnine acts as a competitive antagonist at glycine receptors, blocking glycine's inhibitory effects. This disinhibition causes unchecked excitatory signals in motor neurons, resulting in increased muscle tone, hyperreflexia, and severe muscle spasms, explaining the 'stiff as a board' presentation.
Recommended video:
2:47
Sensory Receptors

Clinical Presentation of Strychnine Poisoning

Strychnine poisoning manifests as muscle rigidity, twitching, and heightened reflexes due to loss of inhibitory control over motor neurons. Unlike ecstasy, which primarily affects serotonin pathways, strychnine's blockade of glycine receptors leads to characteristic convulsions and muscle stiffness seen in this patient.
Recommended video:
4:11
Free Antigens vs. Presented Antigens on APCs
Related Practice
Textbook Question

Local anesthetics block voltage-gated Na⁺ channels. General anesthetics are thought to activate chemically gated Cl⁻ channels, thereby rendering the nervous system quiescent while surgery is performed. What specific process do anesthetics impair, and how does this interfere with nerve impulse transmission?

1
views
Textbook Question

Rochelle developed multiple sclerosis when she was 27. After eight years she had lost a good portion of her ability to control her skeletal muscles. How did this happen?

1
views
Textbook Question

Explain both the anatomical and functional divisions of the nervous system. Include the subdivisions of each.