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Ch. 25 Fluid, Electrolyte, and Acid-Base Homeostasis
Amerman- Human Anatomy & Physiology 3e
Amerman3rd EditionHuman Anatomy & PhysiologyISBN: 9780138247201, 9780138247928, 9780138201814Not the one you use?Change textbook
Chapter 25, Problem 11

The biggest source of metabolic acids in the body is:
a. Lactic acid
b. Ketone bodies
c. Carbon dioxide
d. Uric acid

Verified step by step guidance
1
Understand the context of the question: The problem is asking about the primary source of metabolic acids in the body. Metabolic acids are substances that can lower the pH of body fluids when they accumulate.
Review the options provided: a) Lactic acid, b) Ketone bodies, c) Carbon dioxide, and d) Uric acid. Each of these substances can contribute to acidity in the body under certain conditions, but the question is asking for the 'biggest source.'
Recall the role of carbon dioxide (CO₂) in the body: CO₂ is a byproduct of cellular respiration and is constantly produced in large quantities by cells. It combines with water (H₂O) in the blood to form carbonic acid (H₂CO₃), which dissociates into hydrogen ions (H⁺) and bicarbonate ions (HCO₃⁻), contributing to the body's acid-base balance.
Compare the other options: Lactic acid is produced during anaerobic metabolism (e.g., intense exercise), but its production is not as constant or large-scale as CO₂. Ketone bodies are produced during prolonged fasting or uncontrolled diabetes, and uric acid is a byproduct of purine metabolism, but neither is as significant a source of metabolic acids as CO₂.
Conclude that carbon dioxide is the biggest source of metabolic acids in the body because it is continuously produced in large amounts during normal cellular respiration and directly contributes to acid formation through the carbonic acid-bicarbonate buffer system.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Metabolic Acids

Metabolic acids are byproducts of various biochemical processes in the body, primarily resulting from the metabolism of carbohydrates, fats, and proteins. They can affect the body's pH balance and are crucial in understanding metabolic pathways. Common metabolic acids include lactic acid, ketone bodies, and carbon dioxide.
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Introduction to Metabolism

Carbon Dioxide as a Metabolic Byproduct

Carbon dioxide (CO2) is a significant metabolic byproduct produced during cellular respiration, particularly in the Krebs cycle. It is generated when glucose and fatty acids are oxidized for energy. CO2 is transported in the blood to the lungs for exhalation, playing a vital role in maintaining acid-base balance in the body.
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Acid-Base Balance

Acid-base balance refers to the mechanisms the body uses to maintain the pH of the blood and other fluids within a narrow range. This balance is crucial for normal cellular function and is influenced by the production and elimination of metabolic acids. Disruptions in this balance can lead to conditions such as acidosis or alkalosis.
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